Hong Kong: A staff of researchers has developed an inhalable dry powder formulation of tamibarotene — a repurposed drug — which has confirmed broad-spectrum antiviral exercise towards SARS-CoV-2, MERS-CoV and influenza A H1N1 virus following pulmonary supply in animal fashions.
Tamibarotene is offered as an oral pill for the therapy of acute promyelocytic leukemia presently marketed in Japan. However when a excessive dose is run to compensate for the inadequate lung distribution, poisonous uncomfortable side effects are anticipated due to the in depth systemic publicity.
Against this, pulmonary supply is a non-invasive administration route that may maximise native focus within the lung and cut back systemic publicity, thereby decreasing the danger of adversarial results and bettering therapeutic efficacy.
The staff, led by the College of Hong Kong (HKUMed), ready the inhaled dry powder formulation of tamibarotene by spray freeze drying, a particle engineering method that mixes spray freezing and freeze drying to supply particles with glorious aerosol properties for inhalation.
The researchers discovered {that a} dose of tamibarotene powder delivered by intratracheal administration considerably lowered virus titer and viral RNA load of SARS-CoV-2 within the hamsters’ lungs, and the antiviral efficacy was akin to intratracheally administered remdesivir.
The broad-spectrum anti-coronavirus exercise of inhaled tamibarotene powder was additionally demonstrated within the MERS-CoV-infected mice mannequin as pre-challenge prophylaxis.
Furthermore, exceptional anti-influenza exercise of tamibarotene powder formulation was demonstrated by the improved survival price of mice and alleviated illness severity when administered both intratracheally as prophylaxis or intranasally as therapy. The findings have been printed on-line in Superior Therapeutics.
“At the moment, there isn’t a inhaled powder formulation of antiviral obtainable in the marketplace for COVID-19 therapy. Tamibarotene dry powder with broad-spectrum antiviral exercise presents a brand new technique for COVID-19 administration, particularly as prophylaxis and therapy for outpatients when in-patient healthcare can’t be offered,” stated Jenny Lam, Affiliate Professor, Division of Pharmacology and Pharmacy, HKUMed.
“With the beneficial security profile of tamibarotene and based mostly on the findings within the current research, scientific trials evaluating inhaled tamibarotene for its security and as at-home therapy for COVID-19 may very well be thought of,” Lam stated.
Inhaled powder formulation of broad-spectrum antiviral medication can be utilized on an outpatient foundation because of the ease of (self-)administration as prevention and therapy for respiratory viral infections, the researchers stated.
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